Insulin resistance, high cholesterol, high blood pressure, inflammation, high blood sugar increase the risk of heart disease (cardiovascular disease), stroke, type 2 diabetes and increase the chance of early death.
Piceatannol is a natural stilbene found in fruits and vegetables that has been reported to have anti-inflammatory properties.
More recently studies have suggested that this stilbene may be beneficial for lowering high cholesterol (hypercholesterolemia), atherosclerosis, and angiogenesis.
What is piceatannol?
Piceatannol is naturally present in a variety of foods typically consumed in the human diet. For example, both red grapes and white grapes contain piceatannol at concentrations of 374 and 43 ng/g, respectively.
Blueberries (Vaccinium berries) contain 138 to 422 ng/g
Passion fruit (Passiflora edulis) contains 4.8 mg/g
Resveratrol is converted to piceatannol
Piceatannol can also be converted in the human body by the cytochrome P450 enzymes.
When you eat fruits or vegetables that contain resveratrol it will then get converted into many different compounds including piceatannol.
Here is a clinical trial that tested resveratrol in patients with colitis.
What have research studies found with piceatannol?
– Piceatannol inhibits adipogenesis (fat formation) in adipocytes (i.e. fat cells).
– Piceatannol inhibits fat synthesis and storage in cell culture models.
– Several studies have shown piceatannol lowers blood sugar in laboratory studies.
– Piceatannol reduces inflammation and oxidative stress in cell culture studies.
Here is what the authors of a recent review said about picetannol
It should be noted that although current evidence on piceatannol action in metabolic disorders is insufficient to recommend the use of this small molecule to treat and prevent human disease, the beneficial effects of piceatannol observed in several metabolic pathways provide a rationale for further study of this bioactive compound.
and
Piceatannol has demonstrated significant radical scavenging activity, even up to 1250-fold higher than resveratrol.
Reference
Kershaw et al. The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review.Journal of Medicinal Food. 2017; Volume 20 (Issue 5): pages 427–438.
His research on plant medicine has led to more than 45 publications and abstracts.This research has been presented at international meetings in the USA, France, Turkey, Peru, Israel, Austria, and Italy.
Categories: Antioxidant, Food, Plant Medicine
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