Clinical trial shows lemon balm improves heart function in angina patients

Lemon balm (Melissa officinalis) is a member of the mint family that has been used medicinally for centuries.

The benefits of lemon balm have been suggested to include as a sedative, carminative, fever reducer, anti-bacterial, blood pressure reducer, and to increase memory, reduce menstrual bleeding and affect the thyroid gland

Clinical studies have suggested that a herbal tea can increase the antioxidant defense system.

A recent study in the Journal of Herbal Medicine evaluate the role of lemon balm for improving lab markers evaluated by echocardiography, exercise stress test, cardiovascular serum biomarkers (LDH and NO), and blood pressure in patients with with chronic stable angina.lemon balm

Read here about plant medicine that has been studied in clinical trials for heart health benefits. 

Here are the details of the study:

Study design: Double blind clinical trial in 73 men and women with chronic stable angina.

Lemon Balm:  Patients consumed 3 grams of lemon balm in the form of capsules for 2 months.  Lemon balm was dried in shade at room temperature for 12 days,  powdered and put into capsules.

Ages: 40 to 75 years old

Study agent: Aerial parts of the plant were collected.  Patients took 3 grams in the form of capsules per day.

Endpoints: Evaluated on the results of echocardiography, exercise stress test, cardiovascular serum biomarkers (LDH and NO), and blood pressure in patients with CSA.

 

 

Here are the main results

Ejection faction (EF) was significantly improved with lemon balm by 2.86% *

Here are natural ways to lower cholesterol with plant ingredients.

Lactate dehydrogenase (LDH) was significantly lowered with lemon balm from 308 to 251 (units per liter)*

Nitric oxide (NO) was significantly higher with lemon balm from 21 to 29 micromolar

Systolic and diastolic pressure were significantly lower with lemon balm.  Systolic blood pressure was decreased by 4 points and diastolic aby 4 points.*

*Statistically significant

 

Here is what the authors had to say

In this randomized short-term intervention study significant improvements were observed in EF, maximum workload, LDH, and NO in patients with CSA receiving lemon balm supplementation.

And

The MO effect on blood pressure could be related to inhibition and/or modulation of ACE by rosmarinic acid (Lee et al., Karthik et al) or the endothelium dependent vasodilatore effect of rosmarinic acid

 

Take away message

The results of this study suggest that a dried lemon balm product taken at a dose of three grams per day may provide clinical benefits to patients with chronic stable angina.  Further studies will be needed to confirm these findings, however, they are consistent with lemon balm studies performed in laboratory models.

 

Reference

Javid et al.  The effects of melissa officinalis on echocardiography, exercise test, serum biomarkers, and blood pressure in patients with chronic stable angina.  Journal of Herbal Medicine

Jeremy Johnson, PharmD, PhD


Categories: Blood Pressure, Clinical Trials, Heart